Cancer, in its essence, occurs when a mutation happens in the DNA strand, causing the cells to grow uncontrollably. This uncontrolled growth can lead to the formation of tumors and spread throughout the body.
However, not all cancers are caused by the same factors. When it comes to pancreatic cancer, one question that often arises is whether family history plays a role. In this blog, we will explore whether pancreatic cancer is genetic or not.
Should You Get Genetic Testing for Pancreatic Cancer?
If you have a family member who has been diagnosed with pancreatic cancer, it may be advisable to consult a doctor for genetic testing. A positive result might give you insights into the increased risk within your family, allowing you to take proactive steps for early detection.
However, if your genetic test results are negative and there is no significant family history of cancer, it generally means you don’t need to undergo further genetic tests at that point.
Increased Risk from Other Types of Cancer in the Family
To find out if pancreatic cancer is genetic or not, consult a pancreatic cancer oncologist. If your family has a history of certain cancers, such as breast, ovarian, or colon cancer, your risk of developing pancreatic cancer may also increase.
This is because several genetic mutations associated with these cancers are shared with those linked to pancreatic cancer. For example, mutations in the BRCA gene (known for its role in breast cancer) are also linked with an increased risk of pancreatic cancer.
The Link to Melanoma
Another type of cancer that may play a significant role in increasing the risk of pancreatic cancer is melanoma. This skin cancer can sometimes be linked to specific genetic mutations that also predispose individuals to pancreatic cancer.
Hereditary Pancreatitis
In some cases, a condition known as hereditary pancreatitis can significantly increase the risk of pancreatic cancer. Hereditary pancreatitis is an inherited disorder that causes inflammation of the pancreas and increases the likelihood of developing pancreatic cancer at an early age.
Which Genes Are Associated with Hereditary Pancreatic Cancer?
Researchers are studying several hereditary syndromes and specific genes that may increase the risk of pancreatic cancer. To find whether pancreatic cancer is genetic, some of the key genes associated with hereditary pancreatic cancer include:
- BRCA1/BRCA2 Mutations: Mutations in these genes, often associated with an increased risk of breast and ovarian cancer, are also linked to pancreatic cancer.
- Cystic Fibrosis: Individuals with cystic fibrosis, a genetic condition affecting the lungs and digestive system, have an increased risk of developing pancreatic cancer.
- Familial Adenomatous Polyposis (FAP): A rare genetic condition that causes the development of numerous polyps in the colon, FAP also increases the risk of pancreatic cancer.
- Familial Atypical Multiple Mole Melanoma (FAMMM): A condition where people develop multiple moles that can become melanoma, increasing their risk for pancreatic cancer as well.
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch Syndrome: A genetic disorder that increases the risk of colorectal, endometrial, and several other cancers, including pancreatic cancer.
- Hereditary Pancreatitis: As mentioned, this genetic condition is a direct cause of increased risk for pancreatic cancer.
Conclusion
In summary, family history can indeed play a significant role in the risk of developing pancreatic cancer. If you have relatives who have been diagnosed with pancreatic cancer, as well as other cancers like breast, ovarian, or melanoma, it’s important to consider genetic testing to understand your risk better. Consult the best pancreatic cancer oncologist in Kolkata to stay updated and aware.